Hodgkin lymphoma — Flashcards

Flashcard 1: Which Herpesvirus is associated with Hodgkin Lymphoma?_____

Answer: EBV

Flashcard 2: Hodgkin lymphoma may present with eosinophilia due to production of _____ by Reed-Sternberg cells (especially mixed cellularity subtype)

Answer: IL-5

Flashcard 3: Which type of lymphoma (Hodgkin or non-Hodgkin) is characterized by contiguous spread? _____

Answer: Hodgkin lymphoma

Flashcard 4: Which virus is strongly associated with the mixed cellularity and lymphocyte depleted subtypes of Hodgkin lymphoma?

Answer: Epstein-Barr Virus (EBV)

Flashcard 5: Lymphocyte Predominant Hodgkins Lymphoma is a rare variant that is characterized by "_____ cells"

Answer: popcorn

Flashcard 6: Reed-Sternberg cells occasionally result in "_____" symptoms (fever, chills, weight loss, night sweats)

Answer: B

Flashcard 7: Which type of lymphoma (Hodgkin or non-Hodgkin) is associated with extranodal involvement? _____

Answer: non-Hodgkin lymphoma

Flashcard 8: Hodgkin's lymphoma _____ type has the most Reed-Sternberg cells

Answer: Lymphocyte depleted

Extra: In Hodgkin lymphoma (HL), the number of Reed-Sternberg (RS) cells is inversely proportional to the number of background lymphocytes: - **Lymphocyte depleted HL**: Most RS cells, worst prognosis. - **Mixed cellularity HL**: Plentiful RS cells. - **Lymphocyte rich HL**: Fewest RS cells, best prognosis.

Flashcard 9: Most common type of testicular lymphoma?

Answer: Diffuse Large B-cell Lymphoma (DLBCL) is the most common; often represents dissemination from an occult primary site.

Extra: - Most common testicular tumor in men aged >60.\n- Highly aggressive; prognosis is generally poor.\n- Bilateral involvement is common (most common bilateral testicular tumor).

Flashcard 10: What kinds of tissue samples can be used for karyotyping?

Answer: blood, bone marrow, amniotic fluid, placental tissue