Chronic leukemias — Flashcards

Flashcard 1: The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome

Answer: Philadelphia

Flashcard 2: Chronic myeloproliferative disorders (except CML) are associated with _____ mutations

Answer: V617F JAK2

Flashcard 3: CML may transform to acute _____ leukemia (2/3rd of cases)

Answer: myeloid

Flashcard 4: Leukemic cell infiltration of liver, spleen, lymph nodes, and _____ is possible

Answer: skin (leukemia cutis)

Flashcard 5: Positive TRAP stain for diagnosis of hairy cell leukemia has been largely replaced with _____

Answer: flow cytometry

Flashcard 6: Grade _____ follicular lymphoma is characterized by small cleaved cells

Answer: 1

Flashcard 7: Does hairy cell leukemia typically present with lymphadenopathy? _____

Answer: No

Flashcard 8: Most common type of testicular lymphoma?

Answer: Diffuse Large B-cell Lymphoma (DLBCL) is the most common; often represents dissemination from an occult primary site.

Extra: - Most common testicular tumor in men aged >60.\n- Highly aggressive; prognosis is generally poor.\n- Bilateral involvement is common (most common bilateral testicular tumor).

Flashcard 9: What kinds of tissue samples can be used for karyotyping?

Answer: blood, bone marrow, amniotic fluid, placental tissue