General Pathology — Flashcards

Trauma may cause _____ platelet dysfunction

Hint: qualitative/quantitative

What is the mode of inheritance of porphyria cutanea tarda? _____

Reticulocytes have a bluish cytoplasm on Wright-Giemsa stain due to presence of residual _____

_____ involves the controlled proliferation of stem cells and differentiated cells

Hint: (hypertrophy or hyperplasia)

--- Do with heme --- Type II Hypersensitivity Disorders - Cytotoxic: Transfusion Reaction - Antibody against _____ - IgM isohemagglutinins formed naturally in response to bacterial flora cause opsonization and complement activation - Leads to hemolysis **Hemolytic Disease of the Newborn (Erythroblastosis fetalis) Antibody = _____ - Formed in _____ mother carrying _____ child - First pregnancy _____ (doesn't have to be viable pregnancy) - Antibody crosses placenta and injures subsequent fetuses - Prevent with _____ (anti-Rh, binds fetal red cells and prevents mothers immune system from reacting) ABO blood typing and screening for other preformed Abs; always done in case of transplants. Universal donor: type _____ Universal recipient: type _____ (Ex) Type A can donate to _____ and _____. Type A can receive donations from _____ and _____. - Anti-B antibodies prevent donation from type B and type AB. HLA Typing - Microcytotoxicity test Tests for MHC _____ Test hundreds of different haplotypes to find a potential match. Cells recognized by antibody will be attacked by complement and thus become leaky and take up dye. HLA Typing - Mixed lymphocyte reaction Tests for MHC class _____ Take donor cells and irradiate them (prevent proliferation). Irradiated cells are mixed with donor cells to see if proliferation occurs. Higher radioactivity (thymidine) signifies _____ compatibility.

What component of the breast is affected in fat necrosis? _____

_____ refers to an increased number of circulating lymphocytes

Asbestos bodies contain _____ and thus may be visualized using a(n) _____ stain

The intermediate filament Cytokeratin is found in _____ cells

Which type of calcification occurs in abnormal, necrotic tissues? _____

Hint: dystrophic or metastatic