Vesiculobullous diseases — Flashcards

Flashcard 1: Which blistering skin disorder is characterized by a "fish net" (reticular) pattern on immunofluorescence? _____

Answer: Pemphigus vulgaris

Flashcard 2: Bullous pemphigoid is due to Ig_____ antibodies against hemidesmosome components (BP180)

Answer: G

Flashcard 3: Which blistering skin disorder is characterized by fever and sloughing of skin at the dermal-epidermal junction? _____

Answer: Stevens-Johnson syndrome

Flashcard 4: Which blistering skin disorder is characterized by a targetoid rash and bullae? _____

Answer: Erythema multiforme

Flashcard 5: Which blistering skin disorder is characterized by acantholysis? _____

Answer: Pemphigus vulgaris

Flashcard 6: The dermatitis herpetiformis that arises with celiac disease is due to _____ deposition at the tips of the dermal papillae

Answer: IgA

Flashcard 7: What is the underlying defect in albinism?

Answer: Deficiency of tyrosinase enzyme or tyrosine transporters (usually AR)

Extra: Clinical findings: Normal melanocyte count, but decreased melanin production. Very pale or white skin, increased risk for skin cancer (especially SCC). Inheritance is usually Autosomal Recessive.