Premalignant skin lesions — Flashcards

Flashcard 1: What area of the body does the acral lentiginous subtype of melanoma typically arise?_____

Answer: Palms or soles

Flashcard 2: What is the prognosis of the lentigo maligna subtype of melanoma? _____

Answer: Good (radial growth, "melanoma in situ")

Flashcard 3: Psoriasis is due to excessive _____ proliferation

Answer: keratinocyte

Flashcard 4: Superficial _____ cell carcinoma may present as a scaling plaque

Answer: basal

Flashcard 5: Which skin cancer presents as an ulcerative red lesion with frequent scale?_____

Answer: Squamous cell carcinoma

Flashcard 6: Which tumor suppressor gene is associated with melanoma and pancreatic cancer?_____

Answer: CDKN2A

Flashcard 7: Which skin disorder presents as rough, "gritty", hyperkeratotic, hypogranulotic scaly plaques? _____

Answer: Actinic keratosis

Flashcard 8: What is the underlying defect in albinism?

Answer: Deficiency of tyrosinase enzyme or tyrosine transporters (usually AR)

Extra: Clinical findings: Normal melanocyte count, but decreased melanin production. Very pale or white skin, increased risk for skin cancer (especially SCC). Inheritance is usually Autosomal Recessive.