Melanocytic nevi — Flashcards

Flashcard 1: Melanoma is often driven by activating mutations in _____ kinase

Answer: BRAF

Flashcard 2: Mutations in which tumor suppressor gene can lead to Melanoma, Pancreatic Cancer, and Dysplastic Nevus Syndrome?_____

Answer: CDKN2A (not p53)

Flashcard 3: What is the most common variant of melanoma?_____

Answer: Superficial spreading

Flashcard 4: _____ nevi are flat macules, most commonly seen in children

Answer: Junctional

Flashcard 5: Melanoma is associated with sunlight exposure and _____ nevi

Answer: dysplastic

Flashcard 6: Dysplastic nevus syndrome is an _____ (inheritance) disorder characterized by formation of dysplastic nevi

Answer: autosomal dominant

Flashcard 7: What is the underlying defect in albinism?

Answer: Deficiency of tyrosinase enzyme or tyrosine transporters (usually AR)

Extra: Clinical findings: Normal melanocyte count, but decreased melanin production. Very pale or white skin, increased risk for skin cancer (especially SCC). Inheritance is usually Autosomal Recessive.