Adnexal tumors — Flashcards

Flashcard 1: Lynch syndrome and some sporadic colorectal carcinomas arise via the _____ instability pathway

Answer: microsatellite

Flashcard 2: Seborrheic keratoses are _____ squamous neoplasms, typically seen on the head, trunk, and extremities in the elderly

Answer: benign

Flashcard 3: On histology, the stromal proliferation in fibroadenomas compresses the _____

Answer: ducts

Flashcard 4: What is the most common somatic malignancy stemming from a cystic teratoma? _____

Answer: Squamous cell carcinoma of skin

Flashcard 5: What is the most common skin cancer?_____

Answer: Basal cell carcinoma

Flashcard 6: Which blistering skin disorder is characterized histologically by a "tombstone" appearance? _____

Answer: Pemphigus vulgaris

Flashcard 7: On histology, cyst formation and _____ mitoses are found in colloid cysts

Answer: rare

Flashcard 8: _____ is a cystic tumor composed of fetal tissue derived from two or three embryologic layers (e.g. hair, teeth, bone, skin, gut, thyroid, etc)

Answer: Cystic teratoma

Flashcard 9: _____ disease is ductal carcinoma in situ that extends up the ducts to the skin of the nipple

Answer: Paget's

Flashcard 10: What is the underlying defect in albinism?

Answer: Deficiency of tyrosinase enzyme or tyrosine transporters (usually AR)

Extra: Clinical findings: Normal melanocyte count, but decreased melanin production. Very pale or white skin, increased risk for skin cancer (especially SCC). Inheritance is usually Autosomal Recessive.