Types of necrosis (coagulative, liquefactive, etc.) — Flashcards

Flashcard 1: Fat necrosis of breast tissue presents as a painless _____ on physical exam

Answer: mass

Extra:   * Necrosis may be tender and painful, as well; "irregular breast mass" Watch Benign Breast Disorders [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-breast-benign-breast-disorders?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/inflammation-and-neoplasia/necrosis/acquire?ref=anki 

Flashcard 2: Niemann Pick disease may present with progressive _____

Answer: neurodegeneration

Extra:   https://onlinemeded.org/spa/metabolism?ref=anki 

Flashcard 3: Which layer of the cerebellum is most affected by global cerebral ischemia? _____

Answer: Purkinje layer

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/neurology/videos/ischemic-cerebrovascular-accidents?index=2] https://onlinemeded.org?ref=anki Atlas: 

Flashcard 4: Ionizing radiation results in the formation of double-stranded breaks in DNA and _____ which damage DNA

Answer: hydroxyl free radicals

Extra:   https://onlinemeded.org?ref=anki 

Flashcard 5: Photoaging results in gradual _____ of the epidermis, allowing the stratum corneum to become desiccated

Answer: thinning

Flashcard 6: Defects in the ubiquitin-proteasome system have been implicated in some cases of _____ disease

Answer: Parkinson

Extra:   https://onlinemeded.org?ref=anki 

Flashcard 7: _____ necrosis is characteristic of chronic ischemia of the lower limb and GI tract

Answer: Gangrenous

Extra:   https://onlinemeded.org/spa/inflammation-and-neoplasia/necrosis/acquire?ref=anki 

Flashcard 8: Are patients with metastatic calcifications usually normocalcemic? _____

Answer: No

Extra:   https://onlinemeded.org?ref=anki 

Flashcard 9: 1. Disaggregation of polysomes (dissociation of rRNA from mRNA) 2. Myofibril relaxation 3. Disaggregation of nuclear granules & clumping of nuclear chromatin 4. Triglyceride droplet accumulation 5. Glycogen loss The above changes are signs of _____ myocyte injury

Answer: reversible

Extra:   https://onlinemeded.org/spa/cardiac?ref=anki 

Flashcard 10: Deposits of lipofuscin are commonly found in the _____, heart, colon, kidney, and eye of elderly individuals; and are caused by lipid peroxidation

Answer: liver

Extra: Lipofuscin usually indicates the physiological aging of cells. It appears as fine, yellow-brown granules in the perinuclear region on H&E stain.