Cell injury — Flashcards

Fat necrosis of breast tissue presents as a painless _____ on physical exam

Niemann Pick disease may present with progressive _____

Which layer of the cerebellum is most affected by global cerebral ischemia? _____

Ionizing radiation results in the formation of double-stranded breaks in DNA and _____ which damage DNA

Photoaging results in gradual _____ of the epidermis, allowing the stratum corneum to become dessicated

Defects in the ubiquitin-proteasome system have been implicated in some cases of _____ disease

_____ necrosis is characteristic of chronic ischemia of the lower limb and GI tract

Are patients with metastatic calcifications usually normocalcemic? _____

Deposits of lipofuscin are commonly found in the _____, heart, colon, kidney, and eye of elderly individuals; and are caused by lipid peroxidation

1. Disaggregation of polysomes (dissociation of rRNA from mRNA) 2. Myofibril relaxation 3. Disaggregation of nuclear granules & clumping of nuclear chromatin 4. Triglyceride droplet accumulation 5. Glycogen loss The above changes are signs of _____ myocyte injury

Hint: reversible/irreversible