HPV vaccination — Flashcards

Flashcard 1: What is the carcinoma risk associated with HPV6 and HPV11?_____

Answer: Low

Flashcard 2: Which HPV types are associated with high-risk oncogenesis via the actions of E6 and E7 proteins?

Answer: High-risk types (e.g., HPV 16, 18, 31, 33)

Flashcard 3: Laryngeal papillomatosis and condyloma acuminata are caused by what strains of HPV? _____

Answer: HPV 6, HPV 11

Flashcard 4: What is the cancer risk associated with HPV6?_____

Answer: Low

Flashcard 5: What vaccinations should be considered for patients without a spleen?

Answer: encapsulated organisms; specifically S. pneumoniae, H influenzae, N. meningitidis

Extra: Timing of vaccination: • Elective splenectomy: At least 14 days before surgery. • Emergency splenectomy: 14 days after surgery. Patients should also receive the annual Influenza vaccine to reduce the risk of secondary bacterial pneumonia.

Flashcard 6: Explain the rationale for "conjugated" vaccines.

Answer: When a vaccine is based on a polysaccharide capsule antigen, the polysaccharide must be attached to a protein in order to induce sufficient immune response.

Flashcard 7: Considering the relative antigenicity of exotoxins and endotoxins, which class can be used to generate vaccines?

Answer: exotoxins