Small vessel vasculitis — Flashcards

Flashcard 1: What is the characteristic underlying pathology of **Rickettsia** infections?

Answer: Vasculitis (caused by infection of endothelial cells)

Flashcard 2: How does microscopic polyangiitis present differently from granulomatosis with polyangiitis (Wegener)? _____

Answer: Microscopic polyangiitis lacks nasopharyngeal involvement and granulomas

Flashcard 3: What significant laboratory finding is associated with Churg Strauss syndrome (eosinophilic granulomatosis with polyangiitis)?_____

Answer: Positive p-ANCA

Flashcard 4: What vasculitis is associated with polymyalgia rheumatica? _____

Answer: Giant cell (temporal) arteritis

Flashcard 5: The main symptomatic difference between cryoglobulinemic vasculitis and henoch-schonlein purpura is a lack of _____ symptoms

Answer: gastrointestinal

Flashcard 6: Granulomatosis with polyangiitis often presents with kidney-related symptoms, such as _____, red cell casts, and rapidly progressive glomerulonephritis (RPGN)

Answer: hematuria

Flashcard 7: Multiple Sclerosis is an autoimmune condition characterized by _____ of the CNS. Classical CSF findings include oligoclonal IgG bands, while MRI typically shows periventricular plaques. Clinical features often include optic neuritis and internuclear ophthalmoplegia.

Answer: demyelination

Extra: - Demyelination of CNS. - Symptoms: Optic neuritis, MLF syndrome (internuclear ophthalmoplegia), hemiparesis, hemisensory loss, bladder/bowel incontinence. - Charcot's Neurologic Triad: Scanning speech, Intention tremor, Nystagmus. - Diagnosis: Oligoclonal IgG bands in CSF, MRI showing periventricular plaques (Dawson fingers). - Treatment: β-interferon, Glatiramer acetate, Natalizumab. Acute flares: IV Steroids.