Inflammatory myopathies — Flashcards

Flashcard 1: What is the treatment for dermatomyositis and polymyositis? _____

Answer: Corticosteroids, followed by immunosuppressant therapy

Flashcard 2: _____ (anti-Jo-1) autoantibodies are associated with polymyositis and dermatomyositis

Answer: Anti-synthetase

Flashcard 3: Both polymyositis and dermatomyositis are associated with _____ disease

Answer: interstitial lung

Flashcard 4: _____ may present with a "shawl and face" rash

Answer: Dermatomyositis

Flashcard 5: Multiple Sclerosis is an autoimmune condition characterized by _____ of the CNS. Classical CSF findings include oligoclonal IgG bands, while MRI typically shows periventricular plaques. Clinical features often include optic neuritis and internuclear ophthalmoplegia.

Answer: demyelination

Extra: - Demyelination of CNS. - Symptoms: Optic neuritis, MLF syndrome (internuclear ophthalmoplegia), hemiparesis, hemisensory loss, bladder/bowel incontinence. - Charcot's Neurologic Triad: Scanning speech, Intention tremor, Nystagmus. - Diagnosis: Oligoclonal IgG bands in CSF, MRI showing periventricular plaques (Dawson fingers). - Treatment: β-interferon, Glatiramer acetate, Natalizumab. Acute flares: IV Steroids.