Kidney transplantation — Flashcards

Flashcard 1: Reactivation of CMV occurs in the immunosuppressed, such as _____ and AIDS patients

Answer: organ transplant

Flashcard 2: Which type of transplant rejection occurs within weeks to months? _____

Answer: Acute

Flashcard 3: Organ transplant patients are at an increased risk of pneumonia from which herpesvirus?_____

Answer: CMV

Flashcard 4: Chronic heart transplant rejection typically presents as _____

Answer: accelerated atherosclerosis

Flashcard 5: Membranoproliferative glomerulonephritis has a(n) _____ response to corticosteroids

Answer: poor

Flashcard 6: Membranous nephropathy has a(n) _____ response to corticosteroids

Answer: poor

Flashcard 7: Which type of transplant rejection occurs within months to years? _____

Answer: Chronic

Flashcard 8: Post-transplant Lymphoproliferative Disease (PTLD) is the most common malignancy complicating _____ transplantation*

Answer: solid organ

Flashcard 9: Deficient enzyme and accumulated substrate in Fabry disease?

Answer: α-galactosidase A deficiency; accumulation of ceramide trihexoside.

Extra: Inheritance: X-linked recessive (XR) Triad of clinical features: 1. Peripheral neuropathy (episodic pain in hands/feet) 2. Angiokeratomas (reddish-purple skin rash) 3. Hypohidrosis (decreased sweating) Late complications: Renal failure, cardiovascular disease.

Flashcard 10: What are the clinical features and genetics associated with Autosomal Dominant Polycystic Kidney Disease (ADPKD)?

Answer: Clinical features: Flank pain, hematuria, hypertension, progressive renal failure. Associated with: Berry aneurysms, Mitral Valve Prolapse, Liver cysts. Genetics: Mutations in PKD1 (85%, chromosome 16) or PKD2 (15%, chromosome 4).

Extra: Morphology: Bilateral massive enlargement of kidneys with multiple cysts. Inheritance: Autosomal Dominant. PKD1 encodes Polycystin-1; PKD2 encodes Polycystin-2.