Platelet disorders — Flashcards

Flashcard 1: _____ is the most common cause of thrombocytopenia in children and adults

Answer: Immune thrombocytopenic purpura

Flashcard 2: Waldenstrom macroglobulinemia may present with _____ due to defective platelet aggregation

Answer: bleeding

Flashcard 3: The initial treatment for thrombotic thrombocytopenic purpura (TTP) is _____

Answer: Plasmapheresis (plasma exchange)

Extra: TTP is a medical emergency caused by a deficiency or inhibition of the protease **ADAMTS13**, leading to uncleaved vWF multimers and microthrombi. **Key Distinction:** - **TTP:** Requires emergent **plasmapheresis** (plasma exchange) and often corticosteroids. - **Typical HUS (D+ HUS):** Primarily **supportive care** (fluids, dialysis if needed); plasmapheresis is generally not indicated for Shiga-toxin mediated HUS. TTP Pentad: 1. Microangiopathic hemolytic anemia (schistocytes) 2. Thrombocytopenia 3. Fever 4. Neurological symptoms 5. Renal failure

Flashcard 4: Platelet counts < _____/µL lead to increased bleeding after trauma or surgery

Answer: 50,000/µL (50 × 10⁹/L)

Flashcard 5: What is the most common inherited bleeding/coagulation disorder? _____

Answer: von Willebrand disease

Flashcard 6: Which blood transfusion therapy is used to increase platelet count?_____

Answer: Platelets

Flashcard 7: What type of anemia is caused by TTP, HUS, DIC, and HELLP? _____

Answer: Microangiopathic hemolytic anemia

Flashcard 8: Quantitative disorders of primary hemostasis present with symptoms of skin bleeding, such as _____ (1-2 mm)

Answer: petechiae

Flashcard 9: Paroxysmal nocturnal hemoglobinuria is primarily characterized by _____ hemolysis

Answer: intravascular

Flashcard 10: priapism

Answer: spinal trauma, sickle cell disease, medications

Extra: painful, sustained erection not associated with sexual desire or stimulation