Molecular Genetics US Medical PG Flashcards - Medical Study Cards
Master Molecular Genetics with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Molecular Genetics Flashcard Deck - 10 Cards
Flashcard 21: What is the trigger mechanism for the Cre-lox system?
Answer: antibiotic-controlled promoter
Flashcard 22: codominance (genetics)
Answer: both alleles contribute to the phenotype of the heterozygote
Flashcard 23: variable expressivity (genetics)
Answer: phenotype varies among individuals with same genotype (graded concept vs incomplete penetrance which is binary)
Flashcard 24: What are some of the most powerful and unique uses for microarrays?
Answer: gene expression profile (mRNA), SNP detection (usually DNA)
Flashcard 25: How does a microarray work?
Answer: 1. Labeled nucleic acid probes are arranged in a grid.
2. Sample washed over chip and complementary sequences hybridize.
3. Photoscanner detects relative levels of hybridization.
Flashcard 26: incomplete penetrance (genetics)
Answer: not all individuals with the mutant genotype manifest mutant phenotype (a binary concept vs variable expressivity which is graded)
Flashcard 27: pleiotropy (genetics)
Answer: one gene contributes to multiple phenotypic effects
Flashcard 28: loss of heterozygosity (genetics)
Answer: the event which causes a heterozygote to become a homozygote for the mutated allele
Flashcard 29: dominant negative mutation (genetics)
Answer: mutation that not only loses its original function but inhibits the function of the remaining wild-type allele
Flashcard 30: linkage disequilibrium (genetics)
Answer: tendency for certain alleles at linked loci to be inherited together at a rate above the expected rate
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