Rheumatology & Haematology — Flashcards

Flashcard 631: What is the management of pernicious anaemia? _____ vitamin B12

Answer: IM

Flashcard 632: _____ deficiency = ↑ homocysteine + ↑ methylmalonic acid (MMA) Folate deficiency = ↑ homocysteine + normal/↓ methylmalonic acid (MMA)

Answer: Vitamin B12

Flashcard 633: Patient with suspected folate deficiency is treated with folic acid, but then develops rapidly progressive neurological deficits. What is going on? _____

Answer: Concomitant Vitamin B12 deficiency (folic acid precipitates/worsens neurological damage)

Extra: Always rule out Vitamin B12 deficiency before starting folic acid supplementation in patients with megaloblastic anemia.

Flashcard 634: What is the most common cause of vitamin B12 deficiency? _____

Answer: Pernicious anaemia

Flashcard 635: Pernicious anaemia blood smear will show _____ polymorphonuclear cells

Answer: hypersegmented

Flashcard 636: _____ is the autoimmune destruction of intrinsic factor leading to a deficiency in vitamin B12

Answer: Pernicious anaemia

Flashcard 637: _____ & folate deficiencies are the primary causes of megaloblastic anaemia

Answer: Vitamin B12

Flashcard 638: Vitamin B12 deficiency presents with _____ symptoms ± neurological symptoms

Answer: ANAEMIA

Flashcard 639: Pernicious anaemia will have _____ Hb ↑ MCV ↑ MCH

Answer: ↓

Flashcard 640: Pressure sores present with _____ & non-blanching erythema

Answer: discomfort/tingling