Rheumatology & Haematology — Flashcards

Flashcard 611: _____ is a chronic, systemic, inflammatory disorder that primarily affects the synovial joints due to autoimmunity

Answer: Rheumatoid arthritis (RA)

Flashcard 612: Haemochromatosis Iron Studies: _____ ferritin ↑ (≥ 45-55%) transferrin saturation ↓ total iron-binding capacity (TIBC)

Answer: ↑

Flashcard 613: What is the next-step management for osteoarthritis if oral analgesia is not working? _____

Answer: Intra-articular steroids

Flashcard 614: Primary/hereditary haemochromatosis is a hereditary condition resulting in ↓ _____ (iron regulatory hormone)

Answer: hepcidin

Flashcard 615: Osteoarthritis has _____metrical joint involvement

Answer: asym

Flashcard 616: Osteoarthritis joint x-ray will show _____, osteophytes, subchondral sclerosis, & subchondral cysts

Answer: loss of joint space

Flashcard 617: Patient with suspected folate deficiency is treated with folic acid, but then develops rapidly progressive neurological deficits. What is going on? _____

Answer: Concomitant Vitamin B12 deficiency (folic acid precipitates/worsens neurological damage)

Extra: Always rule out Vitamin B12 deficiency before starting folic acid supplementation in patients with megaloblastic anemia.

Flashcard 618: Pernicious anaemia will have _____ Hb ↑ MCV ↑ MCH

Answer: ↓

Flashcard 619: _____ deficiency = ↑ homocysteine + ↑ methylmalonic acid (MMA) Folate deficiency = ↑ homocysteine + normal/↓ methylmalonic acid (MMA)

Answer: Vitamin B12

Flashcard 620: Vitamin B12 deficiency will have anaemia presenting with _____, pallor, and shortness of breath

Answer: fatigue