Rheumatology & Haematology — Flashcards

Flashcard 481: What HLA subtypes are associated with SLE? _____

Answer: HLA-DR2 & HLA-DR3

Flashcard 482: _____ typically presents as erythematous, scaly plaques with follicular plugging and central scarring/atrophy.

Answer: Discoid Lupus Erythematosus (DLE)

Extra: Discoid Lupus Erythematosus (DLE) features: • Well-demarcated erythematous plaques. • Adherent scale that extends into hair follicles (follicular plugging/carpet tack sign). • Central atrophy, scarring, and telangiectasia. • Most common on sun-exposed areas (face, scalp, ears). • Only 5-10% of DLE patients progress to Systemic Lupus Erythematosus (SLE).

Flashcard 483: What is the symptomatic management of SLE? _____

Answer: NSAIDs

Flashcard 484: Which antibodies are specific, but not sensitive for SLE? _____

Answer: anti-dsDNA and anti-Smith antibodies

Flashcard 485: Which antibody correlates with disease activity & lupus nephritis activity in SLE? _____

Answer: anti-dsDNA

Flashcard 486: _____ is the most common culprit for drug-induced SLE

Answer: Hydralazine

Flashcard 487: Patients with SLE should protect themselves from _____

Answer: UV exposure (sunscreen, clothing)

Flashcard 488: _____ endocarditis is due to sterile vegetations that arise in association with systemic lupus erythematosus (SLE)

Answer: Libman-Sacks

Flashcard 489: -ve _____ = rules OUT lupus

Answer: ANA (sensitive)

Flashcard 490: Spot diagnosis = _____

Answer: Malar rash ("butterfly rash"); Systemic lupus erythematosus