Rheumatology & Haematology — Flashcards

_____ is the terminal phase in CML where it progresses to an acute leukaemia

Accelerated phase of CML presents with fatigue because of _____

What phase do >90% of patients present in with chronic myeloid leukaemia? _____

What are the initial investigations for chronic myeloid leukaemia? _____

Hint: 2

How does _____ affect cells? Initial hyperproliferative phase (esp megakaryocytes) → followed by pancytopenia

Hint: myeloproliferative disorder

What are the confirmatory investigations for polycythaemia vera? _____

Hint: 2

Polycythaemia vera is a form of _____ polycythemia

Hint: primary or secondary

Which form of polycythaemia is associated with lung disease (e.g. COPD / obstructive sleep apnea), congenital heart disease, high altitude, or low birth weight? _____

The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome most commonly seen in chronic myeloid leukaemia (CML)

_____ is a myeloproliferative disorder that leads to erythrocytosis with or without granulocytosis & thrombocytosis