Rheumatology & Haematology — Flashcards

Flashcard 231: Iron deficiency anaemia: _____ iron ↓ ferritin ↓ transferrin saturation ↑ total iron-binding capacity (TIBC)

Answer: ↓

Flashcard 232: What is the most common cause of iron deficiency in females aged 20-50? _____

Answer: Menorrhagia or pregnancy

Flashcard 233: Iron deficiency is caused by 1. dietary _____ 2. increased iron requirement e.g. growth spurt, pregnancy 3. increased iron loss e.g. GI bleeding from malignancy or peptic ulcer disease, menstrual bleeding, frequent blood donation 4. malabsorption e.g. IBD, coeliac disease, bariatric surgery

Answer: deficiencies e.g. chronic undernutrition, cereal-based diet

Flashcard 234: Iron deficiency anemia is associated with a(n) _____ red cell distribution width (RDW)

Answer: increased

Flashcard 235: The underlying _____ of iron deficiency anaemia should be identified & treated first

Answer: cause

Flashcard 236: What is the first-line management of iron deficiency anaemia? _____

Answer: oral ferrous sulfate

Flashcard 237: Ferritin levels can be artificially raised in _____ or inflammatory states

Answer: infection

Flashcard 238: What conditions precipiate sickling in sickle cell anaemia? _____ Acidosis Dehydration

Answer: Hypoxaemia

Flashcard 239: What is the most common cause of pancytopenia? _____

Answer: Megaloblastic anemia

Extra: In India and many developing countries, Megaloblastic anemia (Vitamin B12/Folate deficiency) is the most common cause of pancytopenia. Aplastic anemia is another significant cause.

Flashcard 240: _____ is a decrease ↓ in the number of cells in all three major blood cell lines in the peripheral blood leading to ↓ RBC, WBC, & thrombocytes

Answer: Pancytopenia