Rheumatology & Haematology — Flashcards

Flashcard 91: What Investigation do you need to order before prescribing Biologics in RA?

Answer: Chest X-Ray To look for TB prior to starting biologics for RA, as they can cause reactivation

Flashcard 92: What is the antidote for Methotrexate overdose?

Answer: • Folinic Acid

Flashcard 93: What complication can arise if Trimethoprim is prescribed alongside methotrexate?

Answer: • Bone marrow supression • Severe or fatal pancytopaenia

Flashcard 94: Patients with _____ anemia should be monitored for development of gastric cancer

Answer: pernicious

Flashcard 95: _____ is the most important complication of carbimazole

Answer: Agranulocytosis

Flashcard 96: Haemophilias predominantly affect _____.

Answer: men

Extra: Hemophilia A and B are **X-linked recessive** disorders. Males (XY) have only one X chromosome, so a single defective gene causes the disease. Females (XX) are typically asymptomatic carriers unless they have lyonization (skewed X-inactivation) or Turner syndrome.

Flashcard 97: Alpha thalassaemia _____ is due to --/αα or -α /-α and presents with mild anaemia

Answer: trait

Flashcard 98: Beta thalassaemia _____ is the most severe form of the disease; causes severe anemia a few months after birth

Answer: major (β0/β0)

Flashcard 99: Haemophilia C has an _____ pattern of inheritance

Answer: autosommal recessive

Flashcard 100: What is the supportive management required to improve long-term survival in beta thalassaemia major?\n_____

Answer: Iron chelation therapy (e.g., deferoxamine)