Pharmacogenomics in Psychiatry — Flashcards

Flashcard 1: Drug of choice for rapid cycling Bipolar Affective Disorder (BPAD) is:

Answer: Valproate (Sodium Valproate / Divalproex)

Flashcard 2: Neuro/Psych _____ is a mood stabilizer that may cause hypo-thyroidism as an adverse effect

Answer: Lithium

Flashcard 3: _____ intoxication induces rapid cycling in bipolar disorder

Answer: L-dopa

Flashcard 4: Drug of choice for the treatment of negative symptoms of schizophrenia is:

Answer: Clozapine

Flashcard 5: Use of _____ in patients with bipolar disorder can precipitate acute mania

Answer: antidepressants

Flashcard 6: What is the first-line pharmacotherapy for major depressive disorder (MDD) with psychotic features?

Answer: Combination of an **antidepressant** (usually an SSRI) and an **antipsychotic** (usually a second-generation antipsychotic)

Extra: Electroconvulsive therapy (ECT) is also a first-line treatment option, especially for severe cases, high suicide risk, or when rapid response is required. TCAs are generally not first-line due to their side-effect profile compared to SSRIs.

Flashcard 7: Vilazodone is primarily used to treat _____ disorder and generalized anxiety disorder (off-label)

Answer: major depressive

Flashcard 8: Electroconvulsive therapy produces a _____ seizure in a patient under anesthesia

Answer: grand mal

Flashcard 9: Neuro/Psych _____ is an atypical antipsychotic associated with a dose dependent risk for seizures (neurologic complication)

Answer: Clozapine

Flashcard 10: Neuro/Psych _____ is an ion that is used as a mood stabilizer for bipolar disorder

Answer: Lithium