Non-Bicarbonate Buffer Systems — Flashcards

Flashcard 1: The _____ in red blood cells (from H2CO3) is transported into the plasma in exchange for Cl-

Answer: HCO3-

Flashcard 2: The primary disturbance in metabolic acidosis is a _____ in HCO3-

Answer: decrease

Flashcard 3: The major buffer of the **extracellular fluid** is _____, whereas phosphate is a major buffer of the **intracellular fluid** (and urine).

Answer: bicarbonate

Extra: The bicarbonate buffer system is the primary buffer of the ECF. The phosphate buffer system is a major buffer in the ICF and urine (renal tubules), but plays a minor role in the ECF due to its low concentration. Proteins (like hemoglobin and plasma albumin) also serve as significant buffers in both compartments.

Flashcard 4: In chronic _____, there is an adaptive increase in NH3 synthesis in the cells of the proximal tubule

Answer: acidosis

Flashcard 5: Renal correction of respiratory acidosis includes increased excretion of excess fixed H+ as _____ and NH4+

Answer: titratable acid

Flashcard 6: _____ in pH cause the O2-hemoglobin dissociation curve to shift to the left

Answer: Increases

Flashcard 7: If the pH is reduced from 7.4 to 7.3 with the alveolar PO2 being constant at 100 mmHg, PCO2 would follow line _____.

Answer: 1

Flashcard 8: At _____ urine pH, the HA form of a weak acid exists, thus decreasing excretion

Answer: acidic

Flashcard 9: The arterial blood profile seen in compensated metabolic acidosis is: pH: _____[HCO3-]: decreasedPCO2: decreased

Answer: decreased

Flashcard 10: The arterial blood profile seen in compensated respiratory alkalosis is: pH: _____[HCO3-]: decreasedPCO2: decreased

Answer: increased