Drug Distribution and Protein Binding — Flashcards

Drug Distribution and Protein Binding — Flashcards

Drug Distribution and Protein Binding — Flashcards
#1

About _____% of phenytoin is bound to plasma proteins -mainly albumin

#2

The time taken for the _____ of the drug to be equal to the drug elimination(clearance x concentration) rate is the _____ concentration of the drug.

#3

Loading dose is essential for chloroquine because of its property of _____

#4

Does morphine have a high plasma protein binding?_____

#5

Time for peak plasma concentration (Tmax) of a drug indicates the rate of _____ from the administered site.

#6

All barbiturates (thiopentone, thiamylal, methohexital) other than _____ are metabolized by liver

#7

Thiopental is a barbiturate with a rapid onset and short duration of action due to high potency, and high amount of _____ionized fraction and high lipid solubility

#8

The loading dose of a drug is governed primarily by its _____

#9

What formula is used to calculate loading dose? _____

#10

What formula is used to calculate half-life in first-order elimination kinetics? _____

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