Pharmacogenomics in Cardiovascular Therapeutics — Flashcards

Flashcard 1: Which antimalarials (4) can cause hemolysis in G6PD? _____, Pamaquine, Dapsone, Quinidine

Answer: Primaquine

Flashcard 2: _____ is a urinary antiseptic that can trigger hemolysis in G6PD deficiency patients.

Answer: Nitrofurantoin

Flashcard 3: Drug induced lupus may be caused by _____ acetylation of Isoniazid by NAT-2

Answer: impaired

Flashcard 4: Sulfa drugs are contraindicated in _____, as they can precipitate hemolytic anemia

Answer: G6PD deficiency

Flashcard 5: Slow acetylators of isoniazid are prone to develop _____

Answer: peripheral neuropathy.

Flashcard 6: _____ is the study of the genetic basis for variability in drug action.

Answer: Pharmacogenetics

Flashcard 7: _____ is the MC gene responsible for isoniazid resistance

Answer: Kat G

Extra: 

Flashcard 8: Warfarin sensitivity and metabolism are affected by polymorphisms in the genes for _____ and CYP2C9 (the cytochrome P450 isoform that metabolizes warfarin).

Answer: VKORC1 (vitamin K epoxide reductase)