Pharmacogenomics — Flashcards

Flashcard 1: _____ is the MC gene responsible for isoniazid resistance

Answer: Kat G

Extra: 

Flashcard 2: Metabolism of warfarin is affected by polymorphisms in the genes for _____ and CYP2C9 (p450 enzyme which metabolizes warfarin)

Answer: vitamin K epoxide reductase complex (VKORC1)

Flashcard 3: Which antimalarials (4) can cause hemolysis in G6PD?_____, Artesunate, Dapsone, Quinidine

Answer: Primaquine

Flashcard 4: _____ is a urinary antiseptic that can trigger hemolysis in G6PD deficiency patients.

Answer: Nitrofurantoin

Flashcard 5: Sulfa drugs are contraindicated in _____, as they can precipitate hemolytic anemia

Answer: G6PD deficiency

Flashcard 6: Patient with normal pseudocholinesterase has a dibucaine number of _____

Answer: 80

Flashcard 7: _____ injection, an antisense oligonucleotide, is used in rx of DMD in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping

Answer: Casimersen

Flashcard 8: Patients with POAG and their offspring and siblings are more likely to be steroid _____

Answer: responders

Flashcard 9: Diagnosis of the presence of atypical pseudocholinesterase can be made by _____ number.

Answer: dibucaine

Flashcard 10: _____ injection, an antisense oligonucleotide, is used in rx of DMD in patients who have a confirmed mutation of the DMD gene that is amenable to exon 53 skipping

Answer: Viltolarsen

Flashcard 11: Phenylketonuria can be treated by use of enzyme substitute _____ (phenylalanine ammonia-lyase)

Answer: pegvaliase

Flashcard 12: Which gene mutation can confer resistance to ganciclovir, cidofovir, and foscarnet?_____

Answer: UL54

Flashcard 13: _____ is the study of the genetic basis for variability in drug action.

Answer: Pharmacogenetics

Flashcard 14: Slow acetylators of isoniazid are prone to develop _____

Answer: peripheral neuropathy.

Flashcard 15: Drug induced lupus may be caused by _____ acetylation of Isoniazid by NAT-2

Answer: impaired