Androgens and Anabolic Steroids — Flashcards

Flashcard 1: Enzyme _____ increase the metabolism of oral contraceptives and can cause contraceptive failure

Answer: inducers

Flashcard 2: Ketoconazole and spironolactone both inhibit _____, while ketoconazole additionally inhibits cholesterol desmolase.

Answer: 17α-hydroxylase

Extra: Both drugs also inhibit 17,20-lyase. Inhibition of these enzymes (17α-hydroxylase and 17,20-lyase) contributes to their anti-androgenic effects. Ketoconazole's inhibition of cholesterol desmolase (side-chain cleavage enzyme) blocks the very first step of steroidogenesis, leading to a broad reduction in all adrenal and gonadal steroids.

Flashcard 3: Danazol is a synthetic _____ that acts as a partial agonist at androgen receptors

Answer: androgen

Flashcard 4: Exogenous testosterone causes _____ LDL and decreased HDL

Answer: increased

Flashcard 5: Prostatic adenocarcinoma may be treated with _____ analogs (e.g. leuprolide) and/or androgen receptor inhibitors (e.g. flutamide)

Answer: GnRH

Flashcard 6: _____ is an anti-estrogenic, anti-progestational, and mildly anabolic drug which acts as a 19-nortestosterone derivative similar to danazol, but with fewer side effects

Answer: Gestrinone

Flashcard 7: Once bound (activated), the glucocorticoid receptor enters the _____ and binds to glucocorticoid response elements to regulate gene transcription

Answer: nucleus

Flashcard 8: gossypol is _____

Answer: a male contraceptive

Extra: 

Flashcard 9: EZY pill contains _____

Answer: LNG 1.5 mg

Extra: 

Flashcard 10: Uses of the SERM **Centchroman (Ormeloxifene)** include _____ and _____

Answer: contraception

Extra: Centchroman is also used in the management of Mastalgia and Fibroadenoma.