Drugs for Heart Failure — Flashcards

Flashcard 1: ACE inhibitors by inhibiting the formation of angiotensin II shifts the renal pressure natriuresis curve to _____

Answer: left

Flashcard 2: Which SGLT-2 inhibitor is associated with decrease in the risk of mortality from cardiovascular causes in diabetic patients?_____

Answer: Empagliflozin

Flashcard 3: Drug of choice for HFrEF (Heart Failure with Reduced Ejection Fraction) is

Answer: Sacubitril/Valsartan (ARNI)

Extra: Sacubitril is a neprilysin inhibitor and Valsartan is an ARB. This combination (ARNI) is now a first-line treatment for HFrEF (Heart Failure with Reduced Ejection Fraction), often preferred over ACE inhibitors or ARBs. isolated Right Heart Failure management primarily focuses on treating the underlying cause (e.g., pulmonary hypertension or left-sided failure) and volume management.

Flashcard 4: Sacubitril is an antihypertensive that may be combined with _____ for the treatment of chronic systolic heart failure

Answer: ARBs

Flashcard 5: Hydralazine combined with a _____ provides a mortality benefit for some patients with heart failure

Answer: nitrate

Flashcard 6: The following is a flower of? _____

Answer: Digitalis Purpurea

Flashcard 7: Cardiovascular/RenalACE inhibitors and ARBs _____ sodium and bicarbonate reabsorption at the proximal convoluted tubule

Answer: decrease

Flashcard 8: Ezetimibe indirectly _____ HMG CoA reductase activity and thus increases cholesterol synthesis by the liver

Answer: increases

Flashcard 9: _____ and Acebutolol are both partial beta-agonists that are contraindicated in angina.

Answer: Pindolol

Flashcard 10: Potent vasodilation (e.g. following hypertensive therapy) may cause hypotension followed by reflex _____ and increased renin levels

Answer: tachycardia