Drugs Used in Gout and Hyperuricemia — Flashcards

Flashcard 1: Which drug useful in gout increases the risk of MI and stroke?_____

Answer: Febuxostat

Flashcard 2: What are the two first-line drugs for the treatment of chronic gout? 1. _____ 2. Febuxostat

Answer: Allopurinol

Flashcard 3: _____ is commonly used in the initial treatment of gout.

Answer: Indomethacin::NSAID

Flashcard 4: The two first-line xanthine oxidase inhibitors used for the treatment of chronic gout (especially in overproduction of uric acid) are _____ and febuxostat.

Answer: allopurinol

Extra: Xanthine oxidase inhibitors (XOIs) are the first-line urate-lowering therapy (ULT) for chronic gout. They are effective for both overproducers and underexcretors of uric acid. 1. **Allopurinol**: The most commonly used first-line agent. 2. **Febuxostat**: A more potent, non-purine selective inhibitor of xanthine oxidase, used as an alternative if allopurinol is not tolerated or is contraindicated.

Flashcard 5: Acute adverse effects of aspirin use are _____ and tinnitus (CN VIII) (ears ringing).

Answer: gastric ulceration

Flashcard 6: The effect of intermediate dose aspirin _____ mg/day is antipyretic and analgesic

Answer: 300-2400

Flashcard 7: Acute gastritis may arise with _____ use due to decreased PGE2

Answer: NSAID

Flashcard 8: Sulfasalazine is an anti-_____ therapy primarily indicated for Rheumatoid Arthritis

Answer: inflammatory

Flashcard 9: Chronic gout due to overproduction is treated with _____ or febuxostat, which inhibit xanthine oxidase

Answer: allopurinol

Flashcard 10: _____ is cetirizine ophthalmic solution used in allergic conjunctivitis

Answer: Zerviate