Wilms Tumor — Flashcards

Flashcard 1: What is the mode of inheritance of familial Wilms tumor?

Answer: Autosomal dominant

Extra: Most Wilms tumors are sporadic (~98%). Familial cases (~1-2%) are inherited in an autosomal dominant pattern with incomplete penetrance.

Flashcard 2: In Wilms tumour, metastasis to the _____ occurs early

Answer: lungs

Flashcard 3: Most unilateral Wilms tumors are treated by _____ followed by nephrectomy.

Answer: chemotherapy

Flashcard 4: What is the most important prognostic factor for Wilms tumor?_____

Answer: Anaplastic histology

Flashcard 5: What is the most common primary renal tumor of childhood?

Answer: Wilms tumor (Nephroblastoma)

Flashcard 6: Wilms tumor is caused by "loss of function" mutations of tumor suppression genes _____ or WT2 on chromosome 11

Answer: WT1

Flashcard 7: The most common presentation for a _____ is abdominal distention with a firm, irregular mass that can cross the midline

Answer: neuroblastoma

Flashcard 8: Wilms tumor presents as a large, _____ flank mass (most common presentation) and/or hematuria.

Answer: unilateral

Flashcard 9: Age younger than _____ year or presentation in adolescence or adulthood is a bad prognostic marker for ALL

Answer: 1