Vascular Pathology — Flashcards

Flashcard 41: _____ is a form of necrotizing, granulomatous vasculitis that classically involves the nasopharynx, lungs, and kidneys

Answer: Granulomatosis with polyangiitis (Wegener)

Flashcard 42: Hemangiomas most often involve the _____ and liver

Answer: skin

Flashcard 43: Hereditary Hemorrhagic Telangiectasia is caused by a disorder of _____ signaling

Answer: TGF-β (Transforming Growth Factor-beta)

Flashcard 44: White thrombi are usually seen with a _____ thrombus

Answer: arterial

Flashcard 45: In SLE, the penicilliary arteries of the spleen show concentric periarterial fibrosis, resulting in characteristic _____ lesions.

Answer: onion-skin (concentric periarterial fibrosis)

Extra: In Systemic Lupus Erythematosus (SLE), the spleen often shows "onion-skin" lesions, which are characterized by concentric periarterial fibrosis of the penicilliary arteries. Note: This is distinct from the "onion-skinning" seen in hyperplastic arteriolosclerosis (malignant hypertension), which involves smooth muscle cell hyperplasia and basement membrane duplication.

Flashcard 46: Behcet's disease will show a _____ predominant infiltrate in perivascular distribution in small and medium size vessels

Answer: neutrophil

Flashcard 47: Mondor's disease maybe associated with protein _____ deficiency

Answer: C

Flashcard 48: _____ is a vascular tumor derived from supporting cells of the blood vessels

Answer: Hemangiopericytoma

Flashcard 49: What is the staining done in epithelioid hemangioendothelioma?

Answer: Factor VIII, CD31, CD34

Flashcard 50: What is another name for Microscopic polyangiitis?

Answer: Microscopic polyarteritis