Renal Transplantation Pathology — Flashcards

Flashcard 1: A **diffuse granular** immunofluorescence pattern (IgG and C3) along the glomerular capillary loops is suggestive of _____:

Answer: Membranous nephropathy

Flashcard 2: MPGN type _____ is associated with subendothelial immune complex deposits

Answer: I

Flashcard 3: _____ glomerulonephritis is characterized by crescents in Bowman's space of the glomeruli (light microscopy)

Answer: Rapidly progressive

Flashcard 4: DPGN is characterized by _____ and sometimes intramembranous immune complexes on electron microscopy

Answer: subendothelial

Flashcard 5: HIV-1-associated nephropathy (HIVAN) a form of _____

Answer: Focal segmental glomerulosclerosis (FSGS) (nephrotic syndrome subtype)

Flashcard 6: Which glomerulonephritis is associated with malignancies, particularly chronic lymphocytic leukemia?_____

Answer: Membranoproliferative glomerulonephritis

Flashcard 7: The given immunoflorescence pattern is suggestive of _____:

Answer: Membranous nephropathy

Flashcard 8: Presence of yellow-colored spherical mass associated with tumor cells invading the renal vein is characteristic of _____ carcinoma

Answer: clear cell

Flashcard 9: _____ crystals on urine microscopy appear as spheres with radial or concentric striations and irregular projections or thorns, referred to as thorn apples

Answer: Ammonium biurate

Flashcard 10: The four major sites of immune complex deposits in glomerular diseases are _____, subendothelial, mesangial, and intramembranous.

Answer: subepithelial

Extra: Specific examples of deposit locations: - **Subepithelial**: Membranous nephropathy, PSGN (humps) - **Subendothelial**: SLE (Class III/IV), MPGN Type I - **Mesangial**: IgA nephropathy, SLE (Class II) - **Intramembranous**: MPGN Type II (Dense Deposit Disease)