Pineal Gland Pathology — Flashcards

Flashcard 1: Cells in insulinoma are _____morphic

Answer: mono

Flashcard 2: What are the 3 tumors associated with **MEN 2A** (caused by a point mutation of the **RET** oncogene)? 1. _____ 2. Pheochromocytoma 3. Parathyroid hyperplasia

Answer: Medullary thyroid carcinoma

Extra: MEN 2B also results from a RET mutation but includes medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas/marfanoid habitus (instead of parathyroid hyperplasia).

Flashcard 3: Aldosterone-producing adenomas show the presence of eosinophilic, laminated cytoplasmic inclusions, known as _____ bodies

Answer: spironolactone

Flashcard 4: Crooke hyaline change is a characteristic feature of the _____, seen in Cushing syndrome

Answer: pituitary gland

Extra: Crooke hyaline change occurs in the anterior pituitary corticotrophs in patients with Cushing syndrome (due to any cause). The normal granular cytoplasm is replaced by homogenous, pale, eosinophilic material consisting of keratin intermediate filaments, representing a response to high glucocorticoid levels.

Flashcard 5: A _____ pattern of chromaffin nests is diagnostic for paraganglioma or pheochromocytoma

Answer: zellballen

Flashcard 6: What type of thyroid carcinoma is illustrated in this histology slide? _____

Answer: medullary carcinoma

Flashcard 7: What type of thyroid carcinoma is illustrated in this histology slide? _____

Answer: anaplastic carcinoma

Flashcard 8: Hurthle cell carcinoma is a variant of _____ thyroid carcinoma consisting of oxyphil (Hurthle, Askanazy) cells containing abundant mitochondria

Answer: follicular

Flashcard 9: In Riedel thyroiditis, fibrosis may extend to _____, thus mimicking anaplastic carcinoma

Answer: local structures (e.g. airway)

Flashcard 10: _____ calcification in the form of psammoma bodies is seen in Papillary thyroid carcinoma.

Answer: Dystrophic