Multiple Endocrine Neoplasia Syndromes — Flashcards

Flashcard 1: Pituitary tumors showing pleomorphism and atypical mitosis were historically termed _____

Answer: atypical adenomas

Flashcard 2: _____ of function mutations in RET proto-oncogene occurs in MEN 2A syndrome.

Answer: Gain

Flashcard 3: What are the 3 tumors associated with **MEN 2A** (caused by a point mutation of the **RET** oncogene)? 1. _____ 2. Pheochromocytoma 3. Parathyroid hyperplasia

Answer: Medullary thyroid carcinoma

Extra: MEN 2B also results from a RET mutation but includes medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas/marfanoid habitus (instead of parathyroid hyperplasia).

Flashcard 4: _____ is the most common tumor of the adrenal medulla in adults

Answer: Pheochromocytoma

Flashcard 5: What type of thyroid carcinoma is illustrated in this histology slide? _____

Answer: medullary carcinoma

Flashcard 6: What type of thyroid carcinoma is illustrated in this histology slide? _____

Answer: anaplastic carcinoma

Flashcard 7: _____ colloid is a characteristic histological finding associated with Graves disease

Answer: Scalloped

Flashcard 8: Hurthle cell carcinoma is a variant of _____ thyroid carcinoma consisting of oxyphil (Hurthle, Askanazy) cells containing abundant mitochondria

Answer: follicular

Flashcard 9: _____ calcification in the form of psammoma bodies is seen in Papillary thyroid carcinoma.

Answer: Dystrophic

Flashcard 10: In Riedel thyroiditis, fibrosis may extend to _____, thus mimicking anaplastic carcinoma

Answer: local structures (e.g. airway)