Adrenal Medullary Disorders — Flashcards

Flashcard 1: The definitive diagnosis of malignancy in pheochromocytomas is based exclusively on the presence of _____

Answer: metastases

Flashcard 2: What are the 3 tumors associated with **MEN 2A** (caused by a point mutation of the **RET** oncogene)? 1. _____ 2. Pheochromocytoma 3. Parathyroid hyperplasia

Answer: Medullary thyroid carcinoma

Extra: MEN 2B also results from a RET mutation but includes medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas/marfanoid habitus (instead of parathyroid hyperplasia).

Flashcard 3: The most common type of endocrine tumors in Carney complex is the _____

Answer: primary pigmented nodular adrenocortical disease

Flashcard 4: Calcitonin and serotonins are responsible for _____ in Medullary thyroid cancer

Answer: diarrhea

Flashcard 5: _____ syndrome is characterized by unilateral cafe-au-lait spots (coast of Maine appearance), precocious puberty, and polyostotic fibrous dysplasia

Answer: McCune-Albright

Flashcard 6: A _____ pattern of chromaffin nests is diagnostic for paraganglioma or pheochromocytoma

Answer: zellballen

Flashcard 7: What type of thyroid carcinoma is illustrated in this histology slide? _____

Answer: medullary carcinoma

Flashcard 8: What type of thyroid carcinoma is illustrated in this histology slide? _____

Answer: anaplastic carcinoma

Flashcard 9: In Riedel thyroiditis, fibrosis may extend to _____, thus mimicking anaplastic carcinoma

Answer: local structures (e.g. airway)

Flashcard 10: _____ calcification in the form of psammoma bodies is seen in Papillary thyroid carcinoma.

Answer: Dystrophic