Bone and Soft Tissue Pathology — Flashcards

_____myositis is characterized by endomysial inflammation with necrotic muscle fibers on biopsy

_____ may present with blue sclerae due to translucent connective tissue over choroidal veins

Osteogenesis imperfecta is most commonly caused by gene defects in _____ and COL1A2

_____ may occur due to carbonic anhydrase II mutations, which leads to loss of the acidic environment necessary for bone resorption

In osteoporosis, cytokines stimulate osteoclast recruitment and _____ the levels of RANKL and decrease the expression of osteoprotegrin

Histology of adamantinoma shows _____ islands in a fibrous stroma

_____ -myositis is characterized by peri -mysial inflammation with perifascicular atrophy on biopsy

_____ and osteoid osteoma do not contain giant cells.

In adults, woven bone is seen _____ and in Paget disease.

_____ tumor is a fibroadenoma-like tumor with overgrowth of the fibrous component, causing 'leaf-like' projections