Osteoporosis — Flashcards

Flashcard 1: What is the earliest clinical symptom of corticosteroid-induced osteonecrosis?

Answer: Pain (typically localized to the joint involved)

Extra: Pain is the earliest clinical symptom of avascular necrosis (AVN). In the hip, it is often felt in the groin and is worsened by weight-bearing. Decreased range of motion (stiffness) and a limp generally develop later, as the disease progresses or the joint surface collapses.

Flashcard 2: _____ is the most common cause of isolated elevated alkaline phosphatase in patients > 40 years old

Answer: Paget disease of bone

Flashcard 3: A patient on prolonged bisphosphonates with suspicion of atypical femur fractures should be diagnosed with a _____

Answer: simple x-ray

Flashcard 4: _____ fracture by radiography, CT, MRI, or VFA is an indication for parathyroidectomy in patients with asymptomatic hyperparathyroidism

Answer: Vertebral

Flashcard 5: _____ fracture is a complication of Paget's disease of bone

Answer: Banana

Flashcard 6: Osteoporosis is most commonly due to decreased _____ levels or increased age

Answer: estrogen

Flashcard 7: Osteopetrosis is due to poor osteo-_____ function, impairing the ability to remodel bone

Answer: clast

Flashcard 8: _____ is caused by an inherited defect in bone resorption

Answer: Osteopetrosis

Flashcard 9: _____ of proximal femur causes Shepherd's crook deformity

Answer: Fibrous dysplasia

Flashcard 10: Gaucher disease is associated with _____ of the femur

Answer: avascular necrosis