Principles of Cancer Diagnosis and Staging — Flashcards

Flashcard 1: What is the most powerful prognostic indicator of multiple myeloma at the time of diagnosis?

Answer: Beta-2 microglobulin

Flashcard 2: What is the recommended management for a patient with Ductal Carcinoma In Situ (DCIS) and a Van Nuys Prognostic Index (VNPI) score of 7, 8, or 9?

Answer: Breast-conserving surgery (excision) + Radiotherapy

Extra: The Van Nuys Prognostic Index (VNPI) guides the treatment of Ductal Carcinoma In Situ (DCIS) based on tumor size, margin width, nuclear grade/necrosis, and age. Scores and recommended management: • 4, 5, 6: Excision alone • 7, 8, 9: Excision + Radiotherapy • 10, 11, 12: Mastectomy

Flashcard 3: Most common paraneoplastic syndrome seen with RCC is _____

Answer: raised ESR

Flashcard 4: _____ is the most common cause of hypercalcemia in hospitalized patients.

Answer: Cancer

Flashcard 5: _____ is the treatment of choice for nasopharyngeal cancer stage III and IV

Answer: Radiotherapy and Chemotherapy

Flashcard 6: The Carcinoembryonic antigen (CEA) is a serum tumor marker that has major associations with _____ and pancreatic cancers

Answer: colorectal

Flashcard 7: _____ syndrome is non-metastatic hepatic dysfunction seen in patients suffering from RCC

Answer: Stauffer

Flashcard 8: _____ lung carcinoma may produce the posterior pituitary hormone ADH leading to SIADH

Answer: Small (oat) cell

Flashcard 9: Proteasomal inhibitors are used to treat _____ and mantle cell lymphoma

Answer: multiple myeloma

Flashcard 10: Lung cancers with a EML4-ALK fusion protein are typically EGFR _____ / KRAS negative*bonus: treat with..?

Answer: negative