Mixed Connective Tissue Disease — Flashcards

Flashcard 1: Limited scleroderma is characterized by skin involvement distal to the elbows and knees, typically affecting the _____ and face.

Answer: fingers

Flashcard 2: Graves disease is associated with _____ myxedema which occurs due to activation of dermal fibroblasts

Answer: pretibial

Flashcard 3: _____ may present with a malar rash that is similar to SLE

Answer: Dermatomyositis

Flashcard 4: Antibodies to the _____ antigen are seen associated with Subacute Cutaneous Lupus Erythematosus

Answer: Ro/SS A

Flashcard 5: _____ may present with Gottron papules, which are red papules on the PIP joints, DIP joints and MCP joints.

Answer: Dermatomyositis

Flashcard 6: The characteristic skin changes seen in **lichenoid tissue reactions** (e.g., Lichen Planus) are _____.

Answer: violaceous, polygonal, flat-topped papules

Extra: Wickham striae (fine white reticular lines) are often visible on the surface of these papules. Histologically, lichenoid reactions are characterized by 'saw-tooth' rete ridges, basal cell vacuolar degeneration, and a band-like lymphocytic infiltrate at the dermo-epidermal junction.

Flashcard 7: _____ may present with a "heliotrope" rash, which is an erythematous periorbital rash

Answer: Dermatomyositis

Flashcard 8: En coup de sabre lesion is seen in juvenile _____, also known as morphea

Answer: localized scleroderma