Diagnostic Methods in Autoimmune Dermatoses — Flashcards

Flashcard 1: _____  is a term used in preference to localized scleroderma , showing sclerosis, fibrosis, and atrophy in the skin and subcutaneous tissues

Answer: Morphoea

Flashcard 2: The rash of neonatal lupus erythematosus can be _____ by UV exposure

Answer: exacerbated

Flashcard 3: Discoid lupus erythematosus is a benign inflammatory disorder of the skin, most frequently involving the _____ and scalp

Answer: face

Flashcard 4: _____ is an autoimmune destruction of hemidesmosomes between basal cells and the underlying basement membrane

Answer: Bullous pemphigoid

Flashcard 5: Erythema multiforme _____ is characterised by mucous membrane involvement

Answer: major

Flashcard 6: Erythema _____ involves the sublaminar connective tissue of the dermis

Answer: multiforme

Flashcard 7: Anti-_____ antibodies are associated with dermatomyositis featuring gottron papules and heliotrope rash

Answer: Mi2

Flashcard 8: The characteristic skin changes seen in **lichenoid tissue reactions** (e.g., Lichen Planus) are _____.

Answer: violaceous, polygonal, flat-topped papules

Extra: Wickham striae (fine white reticular lines) are often visible on the surface of these papules. Histologically, lichenoid reactions are characterized by 'saw-tooth' rete ridges, basal cell vacuolar degeneration, and a band-like lymphocytic infiltrate at the dermo-epidermal junction.

Flashcard 9: _____ may present with a malar rash that is similar to SLE

Answer: Dermatomyositis

Flashcard 10: _____ may present with a "heliotrope" rash, which is an erythematous periorbital rash

Answer: Dermatomyositis