Starvation Adaptation — Flashcards

Thyroid hormone increases the processes of _____, gluconeogenesis, proteolysis, and lipolysis, all of which may provide sources of ATP

Increased glucagon (fasting) leads to increased cAMP and protein kinase A, thus _____ activity of FBPase-2 and decreasing activity of PFK-2

Increased NADH/NAD+ (e.g. due to ethanol) causes increased conversion of _____ -> malate, thus preventing gluconeogenesis

Glucagon causes _____ fatty acid synthesis and increased lipolysis, which shunts substrates towards gluconeogenesis

During fasting and starvation, the priority is to supply sufficient glucose to the _____ and RBCs while preserving protein

Effect of diabetes on hepatic glycolysis: _____ - Lack of PFK-2 activity due to low insulin - Impaired glucose trapping (reduced glucokinase) in the liver leads to hyperglycemia

Glucagon acts on the _____ (primarily) and adipose tissue

_____ deficiency causes a buildup of pyruvate that gets shunted to lactate (via LDH) and alanine (via ALT)