Metabolic Adaptations During Exercise — Flashcards

Which metabolic pathways require an obligate activator? 1. _____2. Urea cycle

Increased glucagon (fasting) leads to increased cAMP and protein kinase A, thus _____ activity of FBPase-2 and decreasing activity of PFK-2

The number of insulin receptors is _____ in starvation and decreased in obesity

Pyruvate kinase is regulated via negative feedback by _____ and alanine

Increased NADH/NAD+ (e.g. due to ethanol) causes increased conversion of _____ -> malate, thus preventing gluconeogenesis

_____ reactions are chemical reactions that form intermediates of a metabolic pathway.

In starvation, the enzyme 5'-deiodinase is _____ in tissues such as skeletal muscle, but not inhibited in the other tissues, such as the brain

In a person starving for more than 18 hours, the source of energy is _____.

Effect of diabetes on hepatic glycolysis: _____ - Lack of PFK-2 activity due to low insulin - Impaired glucose trapping (reduced glucokinase) in the liver leads to hyperglycemia

Glucagon acts on the _____ (primarily) and adipose tissue