Interorgan Metabolite Exchange — Flashcards

Glucagon acts on the _____ (primarily) and adipose tissue

After three days of starvation, the main source of energy for the brain becomes _____ from adipose stores

Urea cycle and Krebs cycle are linked at _____

Increased glucagon (fasting) leads to increased cAMP and protein kinase A, thus _____ activity of FBPase-2 and decreasing activity of PFK-2

In starvation, the enzyme 5'-deiodinase is _____ in tissues such as skeletal muscle, but not inhibited in the other tissues, such as the brain

In a person starving for more than 18 hours, the source of energy is _____.

Effect of diabetes on hepatic glycolysis: _____ - Lack of PFK-2 activity due to low insulin - Impaired glucose trapping (reduced glucokinase) in the liver leads to hyperglycemia

_____ deficiency causes a buildup of pyruvate that gets shunted to lactate (via LDH) and alanine (via ALT)

Glucagon causes _____ fatty acid synthesis and increased lipolysis, which shunts substrates towards gluconeogenesis