Neuromuscular Blocking Agents — Flashcards

Flashcard 1: Sugammadex is a selective relaxant binding agent used to reverse the effects of which class of neuromuscular blockers?

Answer: Aminosteroids (specifically Rocuronium and Vecuronium)

Extra: Sugammadex works by encapsulating (chelating) the drug molecules in a 1:1 ratio. **It is effective against:** * Aminosteroids (Rocuronium > Vecuronium >> Pancuronium) **It is NOT effective against:** * Benzylisoquinolines (e.g., Atracurium, Cisatracurium, Mivacurium) * Depolarizing agents (Succinylcholine)

Flashcard 2: Shortest acting non-depolarizing muscle relaxant not approved by FDA is _____

Answer: gantacurium

Flashcard 3: Which muscle relaxants are safe to use in renal dysfunction?_____

Answer: Atracurium and cis-atracurium

Flashcard 4: Suxamethonium/Succinylcholine can cause severe _____kalemia

Answer: hyper

Flashcard 5: Phase I depolarizing block and non-depolarizing block can be differentiated based on the _____

Answer: train of four ratio

Flashcard 6: What factors have **no effect** on Minimum Alveolar Concentration (MAC)?

Answer: Factors that have **no effect** on MAC include: - Duration of anesthesia - Gender - Height / Weight / Obesity - Thyroid status - Anesthetic metabolism - Acid-base status - Electrolytes (K+, Mg++) - PaCO2 (15-95 mmHg) - PaO2 (>40 mmHg) - Blood Pressure (MAP > 40 mmHg)

Flashcard 7: Hyper_____, Hypercalcemia, Hypermagnesemia, and Acidosis will all decrease the minimum alveolar concentration for an anaesthetic agent

Answer: carbia

Flashcard 8: _____ administration may lead to salivation and lacrimation which can be prevented by premedication with glycopyrrolate

Answer: Ketamine

Flashcard 9: Inhaled anesthetics with _____ solubility in blood have a slower onset of action

Answer: higher

Flashcard 10: Hypo_____, hypotension, hyponatremia and hypoxia will all decrease the minimum alveolar concentration for an anaesthetic agent

Answer: thermia