Wound healing Practice Questions

Question 1

A 30-year-old man comes to the physician for a follow-up examination 1 month after sustaining a chemical burn over the dorsum of his right hand and forearm. Physical examination shows hyperextension of the hand at the wrist. The skin over the dorsum of the wrist is tense and there is a thick, epithelialized scar. Range of motion of the right wrist is restricted. This patient's contracture is most likely due to activity of which of the following cells?

Accepted Answer

Myofibroblasts

Answer

Fibroblasts

Answer

Neutrophils

Answer

Macrophages

Answer

Endothelial cells

Question 2

A 15-year-old female presents to her family physician for an annual school physical exam and check-up. She is accompanied by her mother to the visit and is present in the exam room. The patient has no complaints, and she does not have any past medical problems. She takes no medications. The patient reports that she remains active, exercising 5 times a week, and eats a healthy and varied diet. Which of the following would be the best way for the physician to obtain a more in-depth social history, including sexual history and use of alcohol, tobacco, or recreational drugs?

Accepted Answer

Ask the mother to step outside into the hall for a portion of the visit

Answer

Disallow the mother to be present in the examination room throughout the entirety of the visit

Answer

Give the patient a social history questionnaire to fill out in the exam room

Answer

Ask the patient the questions directly, with her mother still in the exam room

Answer

Speak softly to the patient so that the mother does not hear and the patient is not embarrassed

Question 3

A 56-year-old male died in a motor vehicle accident. Autopsy reveals extensive atherosclerosis of his left anterior descending artery marked by intimal smooth muscle and collagen proliferation. Which of the following is implicated in recruiting smooth muscle cells from the media to intima in atherosclerotic lesions?

Accepted Answer

Platelet-derived growth factor

Answer

Vascular endothelial growth factor

Answer

Factor V Leiden

Answer

IgE

Answer

Prostacyclin

Question 4

A 14-year-old girl is brought to the physician after she accidentally cut her right forearm earlier that morning while working with her mother's embroidery scissors. She has no history of serious illness. The mother says she went to elementary and middle school abroad and is not sure if she received all of her childhood vaccinations. She appears healthy. Her temperature is 37°C (98.6 °F), pulse 90/min, and blood pressure is 102/68 mm Hg. Examination shows a clean 2-cm laceration on her right forearm with surrounding edema. There is no erythema or discharge. The wound is irrigated with water and washed with soap. Which of the following is the most appropriate next step in management?

Accepted Answer

Administer Tdap only

Answer

Administer DTaP only

Answer

No further steps are necessary

Answer

Administer TIG only

Answer

Intravenous metronidazole

Question 5

A 35-year-old male is brought into the emergency department for a trauma emergency. The emergency medical services states that the patient was wounded with a knife on his upper left thigh near the inguinal ligament. Upon examination in the trauma bay, the patient is awake and alert. His physical exam and FAST exam is normal other than the knife wound. Large bore intravenous lines are inserted into the patient for access and fluids are being administered. Pressure on the knife wound is being held by one of the physicians with adequate control of the bleeding, but the physician notices the blood was previously extravasating in a pulsatile manner. His vitals are BP 100/50, HR 110, T 97.8, RR 22. What is the next best step for this patient?

Accepted Answer

Emergent surgery

Answer

CT lower extremities

Answer

Radiograph lower extremities

Answer

Coagulation studies and blood typing/crossmatch

Answer

Tourniquet of proximal lower extremity

Question 6

A 30-year-old woman dies shortly after admission to the emergency department. The family requests an autopsy to determine cause of death. During the autopsy, multiple linear, parallel marks are noted across her wrists. Which of the following patterns suggests these are hesitation marks rather than defensive wounds?

Accepted Answer

Superficial, parallel cuts

Answer

Irregular, scattered marks

Answer

Diagonal, deep lacerations

Answer

Deep, single cuts

Question 7

In a randomized controlled trial studying a new treatment, the primary endpoint (mortality) occurred in 14.4% of the treatment group and 16.7% of the control group. Which of the following represents the number of patients needed to treat to save one life, based on the primary endpoint?

Accepted Answer

1/(0.167 - 0.144)

Answer

1/(0.144 - 0.167)

Answer

1/(0.300 - 0.267)

Answer

1/(0.267 - 0.300)

Answer

1/(0.136 - 0.118)

Question 8

A 28-year-old male presents to his primary care physician with complaints of intermittent abdominal pain and alternating bouts of constipation and diarrhea. His medical chart is not significant for any past medical problems or prior surgeries. He is not prescribed any current medications. Which of the following questions would be the most useful next question in eliciting further history from this patient?

Accepted Answer

"Can you tell me more about the symptoms you have been experiencing?"

Answer

"Does the diarrhea typically precede the constipation, or vice-versa?"

Answer

"Is the diarrhea foul-smelling?"

Answer

"Please rate your abdominal pain on a scale of 1-10, with 10 being the worst pain of your life"

Answer

"Are the symptoms worse in the morning or at night?"

Question 9

A 37-year-old-woman presents to the emergency room with complaints of fever and abdominal pain. Her blood pressure is 130/74 mmHg, pulse is 98/min, temperature is 101.5°F (38.6°C), and respirations are 23/min. The patient reports that she had a laparoscopic cholecystectomy 4 days ago but has otherwise been healthy. She is visiting her family from Nebraska and just arrived this morning from a 12-hour drive. Physical examination revealed erythema and white discharge from abdominal incisions and tenderness upon palpations at the right upper quadrant. What is the most probable cause of the patient’s fever?

Accepted Answer

Wound infection

Answer

Pulmonary atelectasis

Answer

Residual gallstones

Answer

Urinary tract infection

Answer

Pulmonary embolism

Question 10

Three days after being admitted to the hospital because of a fall from the roof of a two-story building, a 27-year-old man is being monitored in the intensive care unit. On arrival, the patient was somnolent and not oriented to person, place, or time. A CT scan of the head showed an epidural hemorrhage that was 45 cm3 in size and a midline shift of 7 mm. Emergency surgery was performed with craniotomy and hematoma evacuation on the day of admission. Perioperatively, a bleeding vessel was identified and ligated. Postoperatively, the patient was transferred to the intensive care unit and placed on a ventilator. His temperature is 37°C (98.6°F), pulse is 67/min, and blood pressure is 117/78 mm Hg. The ventilator is set at a FiO2 of 55%, tidal volume of 520 mL, and positive end-expiratory pressure of 5.0 cm H2O. In addition to intravenous administration of fluids, which of the following is the most appropriate next step in managing this patient's nutrition?

Accepted Answer

Enteral feeding via nasogastric tube

Answer

Oral feeding

Answer

Keep patient NPO

Answer

Total parenteral nutrition

Answer

Enteral feeding using a percutaneous endoscopic gastrostomy (PEG) tube

Wound healing

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Phases of wound healing

Primary vs. secondary intention

Types of wound closure

Factors affecting wound healing

Chronic wounds pathophysiology

Diabetic wounds

Pressure ulcers staging and management

Surgical wound classification

Wound assessment techniques

Advanced wound care products

Negative pressure wound therapy

Hyperbaric oxygen therapy

Scarring process and management

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About Wound healing for USMLE

Lessons in Wound healing

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