Substance Use Disorders Practice Questions

Question 1

For benzodiazepines and barbiturates, which of the following is true?

Accepted Answer

Both have effect on GABA-A chloride channel

Answer

Flumazenil is the antidote for barbiturate

Answer

Cause additive sedation with alcohol

Answer

Thiopentone has short duration of action due to metabolism

Question 2

Which of the following statements is not true regarding benzodiazepines and barbiturates?

Accepted Answer

Flumazenil can be used for severe alcohol withdrawal symptoms

Answer

Both can be used as a sedative hypnotic

Answer

With alcohol it causes CNS depression

Answer

Both act on GABA-A

Question 3

In an uncomplicated case of alcohol withdrawal, which drug can be given safely?

Accepted Answer

Benzodiazepines

Answer

Clonidine

Answer

Morphine

Answer

Disulfiram

Question 4

Two 19-year-old men are referred by their professor and mentor to a psychiatrist for substance abuse management. The two friends have both used different stimulants for 3 years—Drug A and Drug B, respectively. Both use these substances cyclically. Use of Drug A usually lasts for about 12 hours. The cycle for Drug B lasts several days. A month ago, both men visited the emergency room (ER) due to acute intoxication. Clinical features in the emergency department included hypotension, bradycardia, sweating, chills, mydriasis, nausea, and psychomotor agitation. After a urine drug screen, the psychiatrist identifies both the drugs and informs the professor that although both Drug A and Drug B are stimulants, their mechanisms of action are different. Drug A is an alkaloid that is naturally present in the leaves of the coca plant, while it is possible to make Drug B from over-the-counter nasal decongestant products. Which of the following options best describes the mechanism of action of both drugs?

Accepted Answer

Drug A predominantly acts by inhibiting the reuptake of monoamine neurotransmitters (dopamine, serotonin, and norepinephrine) at the synapse, while Drug B predominantly acts by promoting their release from presynaptic terminals.

Answer

Drug A increases norepinephrine activity, while Drug B does not.

Answer

Drug A increases serotonin activity, while Drug B does not.

Answer

Drug A predominantly acts by increasing the release of monoamine neurotransmitters (dopamine, serotonin, and norepinephrine) into the synapse, while Drug B does not.

Answer

Drug A transiently increases the extracellular concentration of dopamine in the reward circuit, while Drug B does not.

Question 5

A 50-year-old man is experiencing withdrawal symptoms, including agitation, anxiety, and seizures, after stopping alcohol. Which of the following is the most appropriate initial treatment?

Accepted Answer

Benzodiazepines

Answer

SSRIs

Answer

Antipsychotics

Answer

Beta-blockers

Question 6

An alcoholic patient presents with psychosis and memory loss. What is the probable diagnosis?

Accepted Answer

Wernicke-Korsakoff syndrome

Answer

Wernicke's encephalopathy

Answer

Acute psychosis

Answer

None of the above

Question 7

Methadone is used to treat withdrawal symptoms of which substance?

Accepted Answer

Heroin

Answer

Cocaine

Answer

Amphetamine

Answer

Barbiturate

Question 8

Jet black pigmentation of the tongue with tactile hallucinations is a feature of which substance use?

Accepted Answer

Cocaine

Answer

Heroin

Answer

Cannabis

Answer

LSD

Question 9

Dissociative Fugue is characterised by

Accepted Answer

Wandering away from home

Answer

Irreversible amnesia

Answer

Gradual recovery

Answer

Normal recall

Question 10

Alcohol dependence is associated with all of the following except?

Accepted Answer

Alcohol amotivational syndrome

Answer

Anxiety disorder

Answer

Dementia

Answer

Sexual dysfunction

Substance Use Disorders

Study Resources

Lessons

Questions

Flashcards

Lessons

Neurobiology of Addiction

Alcohol Use Disorder

Opioid Use Disorder

Cannabis Use Disorder

Stimulant Use Disorders

Sedative, Hypnotic, and Anxiolytic Use Disorders

Tobacco Use Disorder

Hallucinogen-Related Disorders

Substance Withdrawal Syndromes

Pharmacotherapy for Substance Use Disorders

Psychosocial Interventions

Dual Diagnosis Management

Practice Questions

Flashcards

About Substance Use Disorders for NEET-PG

Lessons in Substance Use Disorders

Master Substance Use Disorders