Integrative Physiology Practice Questions

Question 1

Which of the following statements about adiponectin is incorrect?

Accepted Answer

Positive Correlation with BMI

Answer

Secreted by adipose tissue

Answer

Increases FFA oxidation

Answer

Lowers glucose

Question 2

Mr. Murali has 126 mg/dl of fasting plasma glucose. His venous plasma glucose 2h after ingestion of 75g oral glucose load is 149 mg/dl. This patient comes under which stage of WHO diagnostic criteria of diabetes & intermediate hyperglycemia?

Accepted Answer

Diagnosis of diabetes

Answer

Decreased glucose resistance

Answer

IFG - Impaired fasting glucose

Answer

Impaired glucose tolerance

Question 3

Which of the following statements best describes the mechanism of action of insulin on target cells?

Accepted Answer

Insulin binds to a transmembrane receptor on the outer surface of the plasma membrane, activating the tyrosine kinase in the cytosolic domain of the receptor.

Answer

Insulin binds to a receptor on the outer surface of the plasma membrane, activating adenylate cyclase through the Gs protein.

Answer

Insulin binds to a cytoplasmic receptor and is transferred as a hormone receptor complex to the nucleus to modulate gene expression.

Answer

Insulin enters the cell and causes the release of calcium ions from intracellular stores.

Question 4

Metabolic changes seen in starvation include all of the following except?

Accepted Answer

Increased glycolysis

Answer

Ketogenesis

Answer

Protein degradation

Answer

Increased gluconeogenesis

Question 5

Match the following drugs in Column A with their contraindications in Column B.

Accepted Answer

A-4, B-1, C-3, D-2

Answer

A-1, B-3, C-2, D-4

Answer

A-3, B-2, C-4, D-1

Answer

A-2, B-4, C-1, D-3

Question 6

Final common pathway of metabolism of carbohydrate, lipids, and protein metabolism is?

Accepted Answer

TCA

Answer

Gluconeogenesis

Answer

HMP pathway

Answer

Glycolysis

Question 7

Which of the following represents a normal response to an OGTT?

Accepted Answer

Graph D

Answer

Graph A

Answer

Graph B

Answer

Graph C

Question 8

A hyperventilating patient has the following ABG values: pH=7.53, pCO2=20 mmHg, HCO3= 26 mEq/L. What is the most likely diagnosis?

Accepted Answer

Respiratory alkalosis

Answer

Metabolic alkalosis

Answer

Metabolic acidosis

Answer

Respiratory acidosis

Question 9

What is the body's first physiological response to hypoglycemia?

Accepted Answer

Decreased insulin

Answer

Increased glucagon

Answer

Increased cortisol

Answer

Increased norepinephrine

Question 10

Which of the following statements about insulin-mediated transport of glucose is correct?

Accepted Answer

Seen in adipose tissue

Answer

Via GLUT-2

Answer

Main mechanism in RBCs

Answer

Occurs primarily in the brain

Integrative Physiology

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Homeostatic Control Systems

Stress Response and Adaptation

Circadian Rhythms Integration

Physiological Responses to Exercise

Integrated Metabolic Regulation

Thirst and Fluid Balance Integration

Hunger and Satiety Regulation

Physiological Basis of Behavior

Systems Physiology Approach

Physiological Biomarkers

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