Drugs Used in Skin Disorders Indian Medical PG Practice Questions and MCQs
Practice Indian Medical PG questions for Drugs Used in Skin Disorders. These multiple choice questions (MCQs) cover important concepts and help you prepare for your exams.
Drugs Used in Skin Disorders Indian Medical PG Question 1: Which type of dermatitis is evaluated through patch testing?
- A. Atopic dermatitis
- B. Irritant contact dermatitis
- C. Discoid eczema
- D. Contact dermatitis due to allergens (Correct Answer)
Drugs Used in Skin Disorders Explanation: ***Contact dermatitis due to allergens***
- **Patch testing** is specifically used to identify specific **allergens** that trigger an **allergic contact dermatitis** reaction.
- It involves applying suspected allergens to the skin and observing for a localized inflammatory response, indicating delayed type IV hypersensitivity.
*Atopic dermatitis*
- This is a chronic inflammatory skin condition characterized by **eczematous lesions** and severe **pruritus**, often linked to a genetic predisposition and immune dysfunction.
- While allergy testing (e.g., prick tests, blood tests for IgE) might be used to identify triggers, **patch testing** is not the primary diagnostic tool for atopic dermatitis itself.
*Irritant contact dermatitis*
- This type of dermatitis is caused by direct **damage to the skin barrier** from exposure to caustic substances or irritants, not an immune-mediated allergic reaction.
- Diagnosis is usually based on clinical history of exposure and symptom presentation, and **patch testing** is typically negative in these cases.
*Discoid eczema*
- Also known as **nummular dermatitis**, this condition presents with distinctive **coin-shaped lesions** and is often associated with dry skin or skin trauma.
- Its etiology is generally unknown and not attributable to specific allergens detectable by **patch testing**.
Drugs Used in Skin Disorders Indian Medical PG Question 2: Which one of these should not be used in severe widespread psoriasis?
- A. Methotrexate
- B. Oral retinoids
- C. Cyclosporin
- D. Oral glucocorticoids (Correct Answer)
Drugs Used in Skin Disorders Explanation: ***Oral glucocorticoids***
- While they may provide temporary relief, **oral glucocorticoids** can exacerbate psoriasis upon withdrawal, leading to a severe flare-up or **pustular psoriasis**.
- Their long-term use is associated with numerous side effects, making them unsuitable for widespread, chronic conditions like severe psoriasis.
*Methotrexate*
- **Methotrexate** is a systemic agent commonly used for severe psoriasis due to its immune-modulating and anti-proliferative effects.
- It is effective in reducing inflammation and slowing down epidermal cell turnover.
*Oral retinoids*
- **Oral retinoids** like acitretin are effective systemic treatments for severe widespread psoriasis, especially **pustular** and **erythrodermic** forms.
- They work by normalizing keratinocyte proliferation and differentiation.
*Cyclosporin*
- **Cyclosporin** is a potent immunosuppressant widely used for severe psoriasis, particularly when rapid disease control is needed.
- It works by inhibiting T-cell activation and is highly effective in clearing psoriatic lesions.
Drugs Used in Skin Disorders Indian Medical PG Question 3: All of the following are used in systemic therapy of psoriasis except
- A. Methotrexate
- B. Cyclosporine
- C. Oral glucocorticoids (Correct Answer)
- D. Acitretin
Drugs Used in Skin Disorders Explanation: ***Oral glucocorticoids***
- **Oral glucocorticoids** are generally avoided in psoriasis because they can precipitate severe **rebound flares** upon discontinuation or during dose tapering.
- While they can temporarily suppress inflammation, the risk of worsening psoriasis and other systemic side effects makes them unsuitable for long-term systemic therapy.
*Methotrexate*
- **Methotrexate** is a commonly used systemic agent for psoriasis due to its **immunosuppressive** and **anti-proliferative effects**, targeting rapidly dividing cells.
- It works by inhibiting dihydrofolate reductase and is typically given once weekly for chronic plaque psoriasis.
*Cyclosporine*
- **Cyclosporine** is an effective systemic immunosuppressant used for severe, resistant psoriasis, particularly when rapid control is needed.
- It primarily acts by inhibiting **T-cell activation** and proliferation, thereby reducing the inflammatory response in psoriasis.
*Acitretin*
- **Acitretin** is an oral retinoid derivative of vitamin A, used in severe forms of psoriasis, especially **pustular** and **erythrodermic** types.
- It works by modulating **keratinocyte differentiation** and proliferation, helping to normalize skin cell growth.
Drugs Used in Skin Disorders Indian Medical PG Question 4: Match the following scale types with their lesions.
| Scales | Lesions |
| :-- | :-- |
| 1. Collarette scales | a. Pityriasis versicolour |
| 2. Silvery scales | b. Pityriasis rosea |
| 3. Mica-like scales | c. Psoriasis |
| 4. Branny scales | d. Pityriasis lichenoides |
- A. 1-d, 2-c, 3-a, 4-b
- B. 1-c, 2-b, 3-d, 4-a
- C. 1-a, 2-b, 3-d, 4-c
- D. 1-b, 2-c, 3-d, 4-a (Correct Answer)
Drugs Used in Skin Disorders Explanation: ***1-b, 2-c, 3-d, 4-a***
- **Collarette scales** are pathognomonic of **Pityriasis rosea**, appearing as fine, trailing scales around the periphery of oval lesions in a "Christmas tree" distribution.
- **Silvery scales** are the classic hallmark of **Psoriasis**, presenting as thick, adherent, silvery-white scales overlying well-demarcated erythematous plaques.
- **Mica-like scales** are characteristic of **Pityriasis lichenoides**, appearing as thick, shiny, adherent scales that can be peeled off like mica sheets.
- **Branny scales** are typical of **Pityriasis versicolor**, presenting as fine, powdery scales caused by **Malassezia** yeast overgrowth.
*1-d, 2-c, 3-a, 4-b*
- Incorrectly matches **collarette scales with Pityriasis lichenoides**, which typically presents with mica-like scales, not collarette scales.
- Misassociates **mica-like scales with Pityriasis versicolor**, which characteristically has branny (fine, powdery) scales.
*1-c, 2-b, 3-d, 4-a*
- Wrongly pairs **collarette scales with Psoriasis**, which is known for thick silvery scales, not peripheral collarette scales.
- Incorrectly matches **silvery scales with Pityriasis rosea**, which has collarette scales at lesion periphery, not silvery scales.
*1-a, 2-b, 3-d, 4-c*
- Falsely associates **collarette scales with Pityriasis versicolor**, which has branny scales from yeast infection, not collarette scales.
- Mismatches **branny scales with Psoriasis**, which has characteristic thick silvery scales, not fine powdery scales.
Drugs Used in Skin Disorders Indian Medical PG Question 5: A primigravida female presented with erythematous skin changes and lesions consistent with a severe allergic reaction. Which of the following should be the most appropriate treatment?
- A. Psoralen + PUVA
- B. PUVA
- C. Acitretin
- D. Corticosteroids (Correct Answer)
Drugs Used in Skin Disorders Explanation: ***Corticosteroids***
- **Corticosteroids** are the **first-line therapy** for severe allergic reactions due to their potent **anti-inflammatory** and **immunosuppressive** effects.
- They help to stabilize mast cell membranes, reducing the release of inflammatory mediators and suppressing the allergic response.
*Acitretin*
- **Acitretin** is a **retinoid** primarily used for severe **psoriasis** and is **teratogenic**, making it unsuitable for a primigravida and a severe allergic reaction.
- Its mechanism of action involves regulating cell proliferation and differentiation, which is not appropriate for acute allergy management.
*Psoralen + PUVA*
- **Psoralen** combined with **UVA light (PUVA)** is a **phototherapy** treatment used for severe **psoriasis**, **vitiligo**, and **cutaneous T-cell lymphoma**.
- It has a slow onset of action and involves photosensitizers, making it inappropriate for the urgent treatment of a severe allergic reaction.
*PUVA*
- **PUVA** (Psoralen plus UVA light) is a form of **phototherapy** used for chronic skin conditions, not acute allergic reactions.
- The mechanism involves psoralen making the skin more sensitive to UVA light, which then inhibits excessive cell growth and immune activity over time.
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