Hematopathology Practice Questions

Question 1

A bone marrow aspirate shows blast cells with multiple Auer rods arranged in bundles ('faggot cells'). Which molecular finding would confirm acute promyelocytic leukemia?

Accepted Answer

PML-RARA translocation

Answer

BCR-ABL translocation

Answer

AML1-ETO translocation

Answer

inv(16) mutation

Question 2

Which of the following is a characteristic bone marrow finding in myelofibrosis?

Accepted Answer

Increased reticulin fibrosis

Answer

Absence of fibroblasts

Answer

Decreased megakaryocytes

Answer

Hypocellular marrow from onset

Question 3

A peripheral smear with increased neutrophils, basophils, eosinophils, and platelets is highly suggestive of:

Accepted Answer

Chronic myelogenous leukemia

Answer

Acute myeloid leukemia

Answer

Acute lymphoblastic leukemia

Answer

Myelodysplastic syndrome

Question 4

Which condition is most commonly associated with basophilic leukocytosis?

Accepted Answer

Chronic Myeloid Leukemia (CML)

Answer

Acute Myeloid Leukemia (AML)

Answer

Acute Lymphoblastic Leukemia (ALL)

Answer

Chronic Lymphocytic Leukemia (CLL)

Question 5

Pernicious anemia is associated with which of the following pathologies?

Accepted Answer

Gastric pathology

Answer

Renal pathology

Answer

Esophageal pathology

Answer

Oral pathology

Question 6

A 53-year-old male presents with an enlarged supraclavicular lymph node. Examination reveals enlargement of the Waldeyer ring of oropharyngeal lymphoid tissue. There is no hepatosplenomegaly. Lymph node biopsy reveals replacement by a monomorphous population of large lymphoid cells with enlarged nuclei and prominent nucleoli. The CBC is normal except for mild anemia. Immunohistochemical staining and flow cytometry of the node reveals that most lymphoid cells are CD19+, CD10-, CD3-, CD15-, and TdT negative. What is the most likely diagnosis?

Accepted Answer

Diffuse large B-cell lymphoma

Answer

Chronic lymphadenitis

Answer

Hodgkin disease

Answer

Lymphoblastic lymphoma

Question 7

The nucleotide triplet CTC in the sixth position of the beta-globin chain in DNA forms the complementary nucleotide on mRNA that codes for glutamic acid. A point mutation on the beta-globin chain resulting in the nucleotide triplet CAC forms a complementary nucleotide on mRNA that codes for valine. In sickle cell anemia, what is the expected complementary nucleotide triplet on mRNA, read 5' to 3'?

Accepted Answer

GUG

Answer

GAG

Answer

CTC

Answer

GTG

Question 8

Purpura fulminans is seen in?

Accepted Answer

Protein C deficiency

Answer

Protein S deficiency

Answer

AT III deficiency

Answer

Factor 5 Leiden mutation

Question 9

What is the cause of alpha thalassemia?

Accepted Answer

Deletion of alpha genes

Answer

Deletion of beta genes

Answer

Excess of alpha genes

Answer

Single amino acid substitution in alpha chain

Question 10

What is the rarest variety of multiple myeloma?

Accepted Answer

IgE

Answer

IgM

Answer

IgD

Answer

IgG

Hematopathology

Study Resources

Lessons

Questions

Flashcards

Lessons

Anemias: Classification and Approach

Hemolytic Anemias

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Leukemias

Chronic Leukemias

Lymphomas and Lymphoid Neoplasms

Plasma Cell Disorders

Bleeding Disorders

Thrombotic Disorders

Practice Questions

Flashcards

About Hematopathology for NEET-PG

Lessons in Hematopathology

Master Hematopathology