Rheumatology and Immunology Practice Questions

Question 1

Match the following drugs with the targets of their actions:

Drugs:
A. Trastuzumab
B. Infliximab  
C. Sirolimus
D. Imatinib

Targets:
1. BCR-ABL tyrosine kinase
2. mTOR
3. TNF alpha
4. HER2/neu

Accepted Answer

A-4, B-3, C-2, D-1

Answer

A-2, B-3, C-1, D-4

Answer

A-3, B-4, C-2, D-1

Answer

A-4, B-3, C-1, D-2

Question 2

Which of the following conditions is most commonly associated with disease activity in Systemic Lupus Erythematosus (SLE)?

Accepted Answer

Lymphopenia

Answer

Neutropenia

Answer

Thrombocytopenia

Answer

Autoimmune Hemolytic anemia

Question 3

ANA (antinuclear antibody) is seen in all except:

Accepted Answer

RA

Answer

Systemic sclerosis

Answer

Sjogren's syndrome

Answer

SLE

Question 4

All of the following are pattern recognition receptors for extracellular or ingested microbes, except:

Accepted Answer

Killer-cell immunoglobulin receptors (KIRs) - Recognize MHC class I molecules on host cells.

Answer

Toll-like receptors (TLRs) - Detect pathogen-associated molecular patterns (PAMPs).

Answer

NOD-like receptors (NLRs) - Intracellular sensors for microbial components.

Answer

C-type lectin receptors (CLRs) - Recognize carbohydrate structures on microbes.

Question 5

What is the mechanism of action of Tocilizumab?

Accepted Answer

Inhibits binding of IL-6 to its receptor IL-6R

Answer

TNF Alpha inhibition

Answer

IL-18 inhibition

Answer

Inhibits binding of IL-1

Answer

IL-17 inhibition

Question 6

The most specific antibody for Rheumatoid arthritis is?

Accepted Answer

Anti-cyclic citrullinated peptide (anti-CCP) antibody

Answer

Rheumatoid factor

Answer

Antinuclear antibody (ANA)

Answer

Anti-double stranded DNA antibody

Question 7

A 48-year-old female presents to your office with a 1-year history of dry eyes and difficulty swallowing. She complains of blinking frequently and of eye strain while using her computer at work. She also reports stiffness in her knees and lower back. Past medical history is unremarkable and she does not take medications. She denies cigarette or alcohol use. Family history is notable for Hashimoto's thyroiditis in her mother. Physical exam shows dry oral mucosa and enlargement of the parotid glands. Which of the following serologies is likely to be positive in this patient?

Accepted Answer

Anti-SS-A

Answer

Anti-Jo-1

Answer

Anti-dsDNA

Answer

Anti-Smith

Answer

Anti-CCP

Question 8

Which of the following statements about cold agglutinin disease is false?

Accepted Answer

Rituximab is not effective as a therapeutic measure as it can not control hemolysis effectively

Answer

The antibody is usually IgM with an anti-I specificity

Answer

Blood transfusion is not very effective because donor red cells are I-positive and will be rapidly removed

Answer

Hemolysis is more prominent the more the body is exposed to the cold

Question 9

Which of the following is true about rheumatic fever

Accepted Answer

Chorea occurs in the absence of other manifestations after prolonged latent period

Answer

90% of the patients with acute rheumatic fever proceed to rheumatic heart disease

Answer

Characteristic manifestation of carditis in previously unaffected individuals is mitral stenosis

Answer

Isolated aortic valve involvement is most common

Question 10

A patient with rheumatoid arthritis presents with sudden onset wrist drop. What is the most likely cause?

Accepted Answer

Tendon Rupture

Answer

Joint Destruction

Answer

Muscle Weakness

Answer

Nerve Compression

Rheumatology and Immunology

Study Resources

Lessons

Questions

Flashcards

Lessons

Rheumatoid Arthritis

Spondyloarthropathies

Systemic Lupus Erythematosus

Vasculitis Syndromes

Scleroderma and Related Disorders

Inflammatory Myopathies

Crystal Arthropathies

Osteoarthritis

Primary Immunodeficiency Disorders

Autoinflammatory Syndromes

Sjögren's Syndrome

Antiphospholipid Syndrome

Practice Questions

Flashcards

About Rheumatology and Immunology for NEET-PG

Lessons in Rheumatology and Immunology

Master Rheumatology and Immunology